Protein binding of endogenous digoxin-immunoactive factors in human serum and its variation with clinical condition.

@article{Valdes1985ProteinBO,
  title={Protein binding of endogenous digoxin-immunoactive factors in human serum and its variation with clinical condition.},
  author={Roland Valdes and Steven W Graves},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1985},
  volume={60 6},
  pages={1135-43}
}
We previously identified endogenous digoxin-like immunoactivity in serum from pregnant women, newborn infants, and patients in renal failure. This activity is due to an endogenous factor(s) that cross-reacts with antibodies raised against digoxin. Using serum from the above sources as well as serum and urine from normal individuals, we further characterized these immunoreactive factors. The factors are water soluble, heat stable, and neutral in molecular charge. That isolated from serum has an… CONTINUE READING

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