Protein-binding elements establish in the oocyte the primary imprint of the Prader-Willi/Angelman syndromes domain.


Imprinting of the PWS/AS 2.4 Mb domain in the human is controlled by a paternally active imprinting center (PWS-IC). PWS-IC on the maternal allele is methylated and inactivated by an 880-bp sequence (AS-IC) located 30 kb upstream. In this communication, we report the identification of 7 cis acting elements within AS-IC. The elements: DMR, DNS, 2 OCTA… (More)
DOI: 10.1073/pnas.0902087106


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