Protein binding and ivermectin estimations in patients with onchocerciasis.

  title={Protein binding and ivermectin estimations in patients with onchocerciasis.},
  author={Paul Obiekwe Okonkwo and Justina E. Ogbuokiri and E Ofoegbu and Ulrich Klotz},
  journal={Clinical pharmacology and therapeutics},
  volume={53 4},
We measured ivermectin in plasma, urine, and saliva of nine patients with onchocerciasis. The aim was to establish pharmacokinetic parameters and to assess the most facile medium for use in monitoring compliance. Binding of ivermectin to plasma proteins in vitro was also investigated. The mean (+/- SEM) plasma values for the nine subjects were as follows: weight, 66.3 +/- 2.8 kg; dose, 11.11 +/- 0.4 mg; half-life, 56.50 +/- 7.01 hours; clearance, 142.5 +/- 22.6 L/kg; volume of distribution, 9… CONTINUE READING