Protein binding: what does it mean?

@article{Scheife1989ProteinBW,
  title={Protein binding: what does it mean?},
  author={Richard T. Scheife},
  journal={DICP : the annals of pharmacotherapy},
  year={1989},
  volume={23 7-8 Suppl},
  pages={S27-31}
}
Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind… CONTINUE READING