Protein-based organelles in bacteria: carboxysomes and related microcompartments

@article{Yeates2008ProteinbasedOI,
  title={Protein-based organelles in bacteria: carboxysomes and related microcompartments},
  author={Todd O. Yeates and Cheryl A. Kerfeld and Sabine Heinhorst and Gordon C. Cannon and Jessup M. Shively},
  journal={Nature Reviews Microbiology},
  year={2008},
  volume={6},
  pages={681-691}
}
Many bacteria contain intracellular microcompartments with outer shells that are composed of thousands of protein subunits and interiors that are filled with functionally related enzymes. These microcompartments serve as organelles by sequestering specific metabolic pathways in bacterial cells. The carboxysome, a prototypical bacterial microcompartment that is found in cyanobacteria and some chemoautotrophs, encapsulates ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic… Expand
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370 Citations
Highly Influential Citations
21
Background Citations
145
Methods Citations
4

370 Citations

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Citation Type

Biogenesis of a Bacterial Organelle: The Carboxysome Assembly Pathway
TLDR
The results demonstrate that, unlike membrane-bound organelles of eukaryotes, in carboxysomes the interior of the compartment forms first, at a distinct site within the cell, and it is proposed that the principles of car boxysome assembly that are uncovered extend to diverse bacterial microcompartments. Expand
Bacterial microcompartment organelles: protein shell structure and evolution.
TLDR
Current structural, evolutionary, and mechanistic ideas are discussed, along with genomic studies for exploring the function and diversity of this family of bacterial organelles. Expand
The Carboxysome and Other Bacterial Microcompartments
TLDR
Genetic modules encoding BMC shell proteins and the enzymes that they encapsulate are horizontally transferable, suggesting they enable bacteria to adapt to diverse environments. Expand
Bacterial microcompartments moving into a synthetic biological world.
TLDR
The molecular structure of bacterial microcompartments is examined and the potential to engineer these intriguing organelles for biotechnological applications is explored. Expand
The protein shells of bacterial microcompartment organelles.
TLDR
Genomic data indicate that bacterial microcompartment shell proteins are present in a wide range of bacterial species, where they encapsulate varied reactions and point the way for further studies on this fascinating but poorly appreciated class of subcellular structures. Expand
Diverse Bacterial Microcompartment Organelles
TLDR
The growing understanding of MCPs is providing a basis for bioengineering of protein-based containers for the production of chemicals/pharmaceuticals and for use as molecular delivery vehicles. Expand
Bacterial microcompartments
TLDR
This Review focuses on recent insights into the structure, assembly, diversity and function of BMCs. Expand
Self-Assembly, Organisation, Regulation, and Engineering of Carboxysomes: CO2-Fixing Prokaryotic Organelles
Carboxysomes are a group of bacterial microcompartments (BMCs) that encapsulate Rubisco and carbonic anhydrase to enhance CO2 fixation in cells. Through self-assembly of hundreds of proteins into a… Expand
Carboxysomes: cyanobacterial RubisCO comes in small packages
TLDR
Recent advances in understanding the organization and functioning of carboxysomes are summarized, which seem to function by allowing ready passage of HCO3− into the body, but hindering the escape of evolved CO2, promoting the accumulation of CO2 in the vicinity of RubisCO and, consequently, efficient carbon fixation. Expand
Clues to the function of bacterial microcompartments from ancillary genes.
TLDR
The known BMC regulation mechanisms are summarized, how much remains to be uncovered is highlighted, and it is proposed that nucleotides are the likely substrate for an enigmatic uncharacterized BMC of unknown function. Expand
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