Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease.

@article{Rhee2011ProteinbasedHI,
  title={Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease.},
  author={Yong-Hee Rhee and Ji-Yun Ko and M S Chang and Sang-Hoon Yi and Dohoon Kim and C H Kim and Jae-Won Shim and A Young Jo and B. Kim and Hyunsu Lee and Suk-Ho Lee and Wonhee Suh and Chang-Hwan Park and H J Koh and Yong-Sung Lee and Robert Lanza and Kwang-Soo Kim and Sang-Hun Lee},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 6},
  pages={2326-35}
}
Parkinson disease (PD) involves the selective loss of midbrain dopamine (mDA) neurons and is a possible target disease for stem cell-based therapy. Human induced pluripotent stem cells (hiPSCs) are a potentially unlimited source of patient-specific cells for transplantation. However, it is critical to evaluate the safety of hiPSCs generated by different reprogramming methods. Here, we compared multiple hiPSC lines derived by virus- and protein-based reprogramming to human ES cells (hESCs… CONTINUE READING

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