Protein arylation precedes acetaminophen toxicity in a dynamic organ slice culture of mouse kidney.

@article{Hoivik1996ProteinAP,
  title={Protein arylation precedes acetaminophen toxicity in a dynamic organ slice culture of mouse kidney.},
  author={Debie J Hoivik and Robyn L. Fisher and Klaus Diether Brendel and Allen Jay Gandolfi and Edward A. Khairallah and Steven D. Cohen},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1996},
  volume={34 1},
  pages={
          99-104
        }
}
Acetaminophen (APAP) is an analgesic and antipyretic agent which may cause hepatotoxicity and nephrotoxicity with overdose in man and laboratory animals. In vivo studies suggest that in situ activation of APAP contributes to the development of nephrotoxicity. Associated with target organ toxicity is selective arylation of proteins, with a 58-kDa acetaminophen binding protein (58-ABP) being the most prominent cytosolic target. In this study a mouse kidney slice model was developed to further… CONTINUE READING

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