Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1.

@article{Karkhanis2012ProteinAM,
  title={Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1.},
  author={Vrajesh Karkhanis and Li Wang and Sookil Tae and Y Hu and Anthony N. Imbalzano and Sa{\"i}d Sif},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 35},
  pages={29801-14}
}
Covalent modification of histones by protein arginine methyltransferases (PRMTs) impacts genome organization and gene expression. In this report, we show that PRMT7 interacts with the BRG1-based hSWI/SNF chromatin remodeling complex and specifically methylates histone H2A Arg-3 (H2AR3) and histone H4 Arg-3 (H4R3). To elucidate the biological function of PRMT7, we knocked down its expression in NIH 3T3 cells and analyzed global gene expression. Our findings show that PRMT7 negatively regulates… CONTINUE READING
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