Protein arginine methylation regulates insulin signaling in L6 skeletal muscle cells.

@article{Iwasaki2007ProteinAM,
  title={Protein arginine methylation regulates insulin signaling in L6 skeletal muscle cells.},
  author={Hiroaki Iwasaki and Toshihiko Yada},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={364 4},
  pages={
          1015-21
        }
}
Protein N-arginine methyltransferase (PRMT)1 catalyzes arginine methylation in a variety of substrates, although the potential role of PRMT1 in insulin action has not been defined. We therefore investigated the effect of PRMT1-mediated methylation on insulin signaling and glucose uptake in skeletal L6 myotubes. Exposure of L6 myotubes to insulin rapidly induced translocation of PRMT1 and increased its catalytic activity in membrane fraction. Several proteins in the membrane fraction were… CONTINUE READING

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