Protein arginine methylation: a new handle on T lymphocytes?

@article{Parry2010ProteinAM,
  title={Protein arginine methylation: a new handle on T lymphocytes?},
  author={Richard V. Parry and Stephen Geoffrey Ward},
  journal={Trends in immunology},
  year={2010},
  volume={31 4},
  pages={164-9}
}
Protein arginine methylation has emerged as a key regulator of signal transduction with an important role in T lymphocyte activation. The predominant methyl transferase PRMT-1 is highly expressed in T helper cells, and ligation of the T cell antigen and costimulatory receptors, induces arginine methylation on several cytoplasmic proteins. Global inhibition of methyl transferases can result in signaling defects in CD4 T cells and profound immunosuppression. Here we suggest that manipulating… CONTINUE READING

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