Protein and lipid nitration: role in redox signaling and injury.

  title={Protein and lipid nitration: role in redox signaling and injury.},
  author={Homero Rubbo and Rafael Radi},
  journal={Biochimica et biophysica acta},
  volume={1780 11},
Protein and lipid nitration represent novel footprints of oxidative and nitrative stress processes. In this review, we first discuss the mechanisms of formation of protein 3-nitrotyrosine and nitrated fatty acids as well as their key biological and signaling actions. Elevation of protein 3-nitrotyrosine levels is associated to tissue injury, and some specific nitrated proteins play a causative role in disease progression; on the other hand, the substantiation on the role of tyrosine nitration… CONTINUE READING

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