Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA.

@article{Orr1998ProteinAM,
  title={Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA.},
  author={Jessica Orr and Paul J. Hagerman and James R Williamson},
  journal={Journal of molecular biology},
  year={1998},
  volume={275 3},
  pages={453-64}
}
The Bacillus stearothermophilus ribosomal protein S15 binds to the central domain of the 16 S rRNA inducing a conformational change in a three-way helical junction. To understand the nature of this conformational change, extended-helical junctions were prepared to examine the effects of S15 or Mg2+ binding on the relative helical orientation using native gel electrophoretic mobility and transient electric birefringence. The free junction is planar with approximately 120 degrees interhelical… CONTINUE READING

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