Protein aggregation in crowded environments

@inproceedings{Ellis2006ProteinAI,
  title={Protein aggregation in crowded environments},
  author={R. Ellis and A. Minton},
  booktitle={Biological chemistry},
  year={2006}
}
Abstract The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem. 
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