• DOI:10.1038/nm1066
Corpus ID: 205383483

Protein aggregation and neurodegenerative disease

@article{Ross2004ProteinAA,
  title={Protein aggregation and neurodegenerative disease},
  author={C. Ross and M. Poirier},
  journal={Nature Medicine},
  year={2004},
  volume={10 Suppl 2},
  pages={S10-S17}
}

C. Ross, M. Poirier

Published 2004

Biology, Medicine

Nature Medicine

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates usually consist of fibers containing misfolded protein with a β-sheet conformation, termed amyloid. There is partial but not perfect overlap among the cells in which abnormal… CONTINUE READING

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