Protein aggregation and neurodegenerative disease

  title={Protein aggregation and neurodegenerative disease},
  author={C. Ross and M. Poirier},
  journal={Nature Medicine},
  volume={10 Suppl 2},
  • C. Ross, M. Poirier
  • Published 2004
  • Biology, Medicine
  • Nature Medicine
  • Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation. The aggregates usually consist of fibers containing misfolded protein with a β-sheet conformation, termed amyloid. There is partial but not perfect overlap among the cells in which abnormal… CONTINUE READING
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