Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

@article{Stefani2003ProteinAA,
  title={Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution},
  author={M. Stefani and C. Dobson},
  journal={Journal of Molecular Medicine},
  year={2003},
  volume={81},
  pages={678-699}
}
The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic feature of more than 20 degenerative conditions affecting either the central nervous system or a variety of peripheral tissues. As these conditions include Alzheimer's, Parkinson's and the prion diseases, several forms of fatal systemic amyloidosis, and at least one condition associated with medical intervention (haemodialysis), they are of enormous importance in the context of present-day human health… Expand
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