Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.

@article{Gianni2010ProteinAA,
  title={Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy.},
  author={Davide Gianni and Airong Li and Giuseppina Tesco and Kenneth M McKay and John B. Moore and Kunal P Raygor and Marcello Rota and Judith K. Gwathmey and George William Dec and Thomas Aretz and Annarosa Leri and Marc J. Semigran and Piero Anversa and Thomas E Macgillivray and Rudolph E. Tanzi and Federica del Monte},
  journal={Circulation},
  year={2010},
  volume={121 10},
  pages={1216-26}
}
BACKGROUND Heart failure is a debilitating condition resulting in severe disability and death. In a subset of cases, clustered as idiopathic dilated cardiomyopathy (iDCM), the origin of heart failure is unknown. In the brain of patients with dementia, proteinaceous aggregates and abnormal oligomeric assemblies of beta-amyloid impair cell function and lead to cell death. METHODS AND RESULTS We have similarly characterized fibrillar and oligomeric assemblies in the hearts of iDCM patients… CONTINUE READING