Protein aggregates: an aging factor involved in cell death.

  title={Protein aggregates: an aging factor involved in cell death.},
  author={Etienne Maisonneuve and Benjamin Ezraty and Sam Dukan},
  journal={Journal of bacteriology},
  volume={190 18},
In a previous study, we demonstrated the presence of protein aggregates in an exponentially grown Escherichia coli culture. In light of these observations, protein aggregates could be considered damage to cells that is able to pass from one generation to the next. Based on the assumption that the amount of aggregate protein could represent an aging factor, we monitored this amount in a bacterial culture during senescence. In doing so, we observed (i) a significant increase in the amount of… CONTINUE READING