Protein adsorption on 18-alkyl chains immobilized on hydroxyl-terminated self-assembled monolayers.

@article{Gonalves2005ProteinAO,
  title={Protein adsorption on 18-alkyl chains immobilized on hydroxyl-terminated self-assembled monolayers.},
  author={In{\^e}s Castro Gonçalves and M Cristina L Martins and M{\'a}rio A Barbosa and Buddy D. Ratner},
  journal={Biomaterials},
  year={2005},
  volume={26 18},
  pages={
          3891-99
        }
}
Surfaces of devices that contact blood accumulate adsorbed and denatured proteins perhaps triggering activation of the coagulation system. A renewable layer of albumin would biologically "passivate" the surface and prevent thrombus formation. Based on the approach of selectively binding albumin to fatty acids, different percentages of a compound with 18 carbons (C18) were immobilized on OH-terminated self-assembled monolayers (SAMs). Fourier transform infrared reflection absorption spectroscopy… CONTINUE READING
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