Protein adducts of malondialdehyde and 4-hydroxynonenal in livers of iron loaded rats: quantitation and localization.

@article{Khan2002ProteinAO,
  title={Protein adducts of malondialdehyde and 4-hydroxynonenal in livers of iron loaded rats: quantitation and localization.},
  author={Mahjabeen Khan and Xiaohong Wu and Ulka R Tipnis and G. A. Shakeel Ansari and Paul J. Boor},
  journal={Toxicology},
  year={2002},
  volume={173 3},
  pages={193-201}
}
Pathophysiological mechanisms for hepatocellular injury, fibrosis and/or cirrhosis in hepatic iron overload are poorly understood. An increase in intracellular transit pool of iron can catalyze peroxidation of lipids to produce reactive aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE). Covalent binding of such lipid aldehydes with proteins may cause impairment in cellular function and integrity. This investigation was focused on quantitative determination of MDA and HNE… CONTINUE READING
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