Protein adduct formation as a molecular mechanism in neurotoxicity.

  title={Protein adduct formation as a molecular mechanism in neurotoxicity.},
  author={Richard M LoPachin and Anthony P Decaprio},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={86 2},
Chemicals that cause nerve injury and neurological deficits are a structurally diverse group. For the majority, the corresponding molecular mechanisms of neurotoxicity are poorly understood. Many toxicants (e.g., hepatotoxicants) of other organ systems and/or their oxidative metabolites have been identified as electrophiles and will react with cellular proteins by covalently binding nucleophilic amino acid residues. Cellular toxicity occurs when adduct formation disrupts protein structure and… CONTINUE READING
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