Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information.

@article{Levy2012ProteinAI,
  title={Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information.},
  author={Emmanuel D. Levy and Stephen W. Michnick and Christian R. Landry},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2012},
  volume={367 1602},
  pages={2594-606}
}
In eukaryotic cells, protein phosphorylation is an important and widespread mechanism used to regulate protein function. Yet, of the thousands of phosphosites identified to date, only a few hundred at best have a characterized function. It was recently shown that these functional sites are significantly more conserved than phosphosites of unknown function, stressing the importance of considering evolutionary conservation in assessing the global functional landscape of phosphosites. This leads… CONTINUE READING
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