Protein Tyrosine Phosphatases in the Human Genome

@article{Alonso2004ProteinTP,
  title={Protein Tyrosine Phosphatases in the Human Genome},
  author={Andr{\'e}s Gayt{\'a}n de Ayala Alonso and Joanna Sasin and Nunzio Bottini and Ilan Friedberg and Iddo Friedberg and Andrei Osterman and Adam Godzik and Tony Hunter and Jack Dixon and Tomas M. Mustelin},
  journal={Cell},
  year={2004},
  volume={117},
  pages={699-711}
}
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed. 
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