Protein-Tyrosine Kinase Activity Profiling in Knock Down Zebrafish Embryos

  title={Protein-Tyrosine Kinase Activity Profiling in Knock Down Zebrafish Embryos},
  author={Simone Lemeer and Chris Jopling and Faris Naji and Rob Ruijtenbeek and Monique Slijper and Albert J. R. Heck and Jeroen den Hertog},
  journal={PLoS ONE},
  pages={355 - 365}
BACKGROUND Protein-tyrosine kinases (PTKs) regulate virtually all biological processes. PTKs phosphorylate substrates in a sequence-specific manner and relatively short peptide sequences determine selectivity. Here, we developed new technology to determine PTK activity profiles using peptide arrays. The zebrafish is an excellent model system to investigate signaling in the whole organism, given its wealth of genetic tools, including morpholino-mediated knock down technology. We used zebrafish… CONTINUE READING
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