Protein Transfer Free Energy Obeys Entropy-Enthalpy Compensation.

  title={Protein Transfer Free Energy Obeys Entropy-Enthalpy Compensation.},
  author={Eric A Mills and Steven S. Plotkin},
  journal={The journal of physical chemistry. B},
  volume={119 44},
We have found significant entropy-enthalpy compensation for the transfer of a diverse set of two-state folding proteins from water into water containing a diverse set of cosolutes, including osmolytes, denaturants, and crowders. In extracting thermodynamic parameters from experimental data, we show the potential importance of accounting for the cosolute… CONTINUE READING