Protein Supplementation Does Not Affect Myogenic Adaptations to Resistance Training

@article{Reidy2017ProteinSD,
  title={Protein Supplementation Does Not Affect Myogenic Adaptations to Resistance Training},
  author={Paul T. Reidy and Christopher S. Fry and Sherry Igbinigie and Rachel R. Deer and Kristofer Jennings and Mark B. Cope and Ratna Mukherjea and Elena Volpi and Blake B. Rasmussen},
  journal={Medicine \& Science in Sports \& Exercise},
  year={2017},
  volume={49},
  pages={1197–1208}
}
It has been proposed that protein supplementation during resistance exercise training enhances muscle hypertrophy. The degree of hypertrophy during training is controlled in part through the activation of satellite cells and myonuclear accretion. Purpose This study aimed to determine the efficacy of protein supplementation (and the type of protein) during traditional resistance training on myofiber cross-sectional area, satellite cell content, and myonuclear addition. Methods Healthy young men… 

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References

SHOWING 1-10 OF 50 REFERENCES
Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis.
TLDR
Protein supplementation increases muscle mass and strength gains during prolonged resistance-type exercise training in both younger and older subjects.
Effects of whey isolate, creatine, and resistance training on muscle hypertrophy.
TLDR
Although WP and/or CrM seem to promote greater strength gains and muscle morphology during RE training, the hypertrophy responses within the groups varied, and these differences in skeletal muscle morphology may have important implications for various populations and, therefore, warrant further investigation.
Protein Supplementation Does Not Further Increase Latissimus Dorsi Muscle Fiber Hypertrophy after Eight Weeks of Resistance Training in Novice Subjects, but Partially Counteracts the Fast-to-Slow Muscle Fiber Transition
TLDR
In LDM protein supplementation does not further enhance RT-induced muscle fiber hypertrophy nor influence mechanic muscle fiber characteristics but partially counteracts the fast-to-slow fiber shift.
Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial123
TLDR
PB supplementation during 3 mo of RET tended to slightly enhance gains in whole-body and arm LBM, but not leg muscle mass, compared with RET without protein supplementation, although protein supplementation minimally enhanced gains in LBM of healthy young men.
Influence of exercise contraction mode and protein supplementation on human skeletal muscle satellite cell content and muscle fiber growth.
TLDR
In conclusion, isolated concentric knee extensor resistance training appears to constitute a stronger driver of SC content than eccentric resistance training while type II fiber hypertrophy was accentuated when combining concentric resistance training with whey protein supplementation.
Does habitual dietary intake influence myofiber hypertrophy in response to resistance training? A cluster analysis.
TLDR
It is concluded that protein and energy intakes were sufficient to facilitate modest and extreme muscle growth during RT and intrinsic or extrinsic factors other than nutrient ingestion apparently impaired the anabolic response in nonresponders.
Acute dietary protein intake restriction is associated with changes in myostatin expression after a single bout of resistance exercise in healthy young men.
TLDR
It is demonstrated that dietary protein intake does not modulate the post-exercise increase in SC content but modifies myostatin expression in skeletal muscle tissue.
The effects of whey protein with or without carbohydrates on resistance training adaptations
TLDR
Post-exercise supplementation with whey proteins when compared to carbohydrates or combination of proteins and carbohydrates did not have a major effect on muscle size or strength when ingested two to three times a week, however, whey protein may increase abdominal fat loss and relative fat-free mass adaptations in response to resistance training when compared with fast-acting carbohydrates.
Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men.
TLDR
The results indicate that resistance exercise rapidly increases mTOR signaling and may decrease myostatin protein expression in muscle and that whey protein increases and prolongs the m TOR signaling response.
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