Protein Structures Forming the Shell of Primitive Bacterial Organelles

  title={Protein Structures Forming the Shell of Primitive Bacterial Organelles},
  author={Cheryl A. Kerfeld and Michael R. Sawaya and Shiho Tanaka and C. V. Nguyen and Martin L. Phillips and Morgan Beeby and Todd O. Yeates},
  pages={936 - 938}
Bacterial microcompartments are primitive organelles composed entirely of protein subunits. Genomic sequence databases reveal the widespread occurrence of microcompartments across diverse microbes. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. We report three-dimensional crystal structures of multiple carboxysome shell proteins, revealing a hexameric unit as the basic microcompartment building block and showing how… 
The Shells of BMC-Type Microcompartment Organelles in Bacteria
This review updates the understanding of bacterial microcompartment shells, how they are assembled, and how they carry out their functions in molecular transport and enzyme organization.
Bacterial microcompartment organelles: protein shell structure and evolution.
Current structural, evolutionary, and mechanistic ideas are discussed, along with genomic studies for exploring the function and diversity of this family of bacterial organelles.
Structural characterization of hexameric shell proteins from two types of choline-utilization bacterial microcompartments.
Six structures of hexameric shell proteins from type I and type II choline-utilization microcompartments are reported, revealing electrostatic surface properties that are shared between the four types of shell proteins described here.
Atomic-Level Models of the Bacterial Carboxysome Shell
Two proteins of previously unknown function assemble to form pentameric structures whose size and shape are compatible with formation of vertices in an icosahedral shell, and combining these pentamers with the hexamers previously elucidated gives two plausible, preliminary atomic models for the carboxysome shell.
Protein-based organelles in bacteria: carboxysomes and related microcompartments
The carboxysome, a prototypical bacterial microcompartment that is found in cyanobacteria and some chemoautotrophs, encapsulates ribulose-1,5-bisphosphate carboxylase/oxygenase and carbonic anhydrase, and thereby enhances carbon fixation by elevating the levels of CO2 in the vicinity of RuBisCO.
Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell
The crystal structure of an intact shell from Haliangium ochraceum is presented, revealing the basic principles of bacterial microcompartment shell construction and can inform the design and engineering of shells with new functionalities.
Bacterial microcompartments insights into the structure, mechanism, and engineering applications.
  • S. Tsai, T. Yeates
  • Biology
    Progress in molecular biology and translational science
  • 2011


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