Protein Structure Determination by Non-parametric Regression and Knowledge-based Constraints

Abstract

We have devised a non-parametric regression-based approach for the estimation of small- and medium-range inter-residual three-dimensional (3d) distances in a protein using only the primary sequence as input. A multivariate analysis of variance technique is used to identify the attributes of the primary sequence that is most effective in determining the… (More)
DOI: 10.1016/S0097-8485(00)00104-2

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