Protein Structure. Determination, Analysis, and Applications for Drug Discovery (Chasman, D. I., ed., Marcel Dekker, New York-Basel, 2003, 606 p., $195)

  • Marcel Dekker
  • Published 2004 in Biochemistry (Moscow)

Abstract

chapters written by internationally distinguished authors. The first section, basically an introduction, consists of one chapter. Here the authors discuss interrelationship between structure of proteins and genome organization. They point to our incomplete knowledge of diversity of protein structures in living system. However, a global project now going on will help to make a catalogue of all natural protein structures. Such protein structure inven tory maybe achieved on the basis of international cooper ation and development of national and international cen ters for study, systematization, and publication of data on structure of various proteins. The second section consists of eight chapters, where approaches to production of proteins, crystalliza tion of membrane proteins, and study of protein struc tures by means of X ray analysis and NMR spec troscopy are discussed. Some chapters describe methods of modification of protein structures, including second ary structure. The third section containing six chapters considers methods of identification of possible errors during design of models of protein tertiary structure. This section also includes a description of the principles of evolutionary classification of protein structures and use of data on pro tein structure for drug design based on structure of biolog ically active proteins such as serine proteases, kinases, phosphatases, and their inhibitors. A special chapter in this section introduces the European Bioinformatics Institute (UK, web site http://www.ebi.ac.uk) founded in 1995. This institute has huge database of protein structures. The fourth section deals with some problems related to use of structural data for drug design. Particularly, it con siders dependence of interferon activity on its structure and mechanisms of action of G protein coupled receptor fam ily and their structural relationship with rhodopsin. This book will be useful for biochemists, specialists in bioorganic chemistry, protein structure, and also for biotechnologists and pharmacologists involved in protein structure based drug design. Biochemistry (Moscow), Vol. 69, No. 5, 2004, p. 585. Translated from Biokhimiya, Vol. 69, No. 5, 2004, p. 719. Original Russian Text Copyright © 2004 by Wiederschain.

DOI: 10.1023/B:BIRY.0000029859.75164.91

Cite this paper

@article{Dekker2004ProteinSD, title={Protein Structure. Determination, Analysis, and Applications for Drug Discovery (Chasman, D. I., ed., Marcel Dekker, New York-Basel, 2003, 606 p., \$195)}, author={Marcel Dekker}, journal={Biochemistry (Moscow)}, year={2004}, volume={69}, pages={585-585} }