Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling.

@article{Brautigan2013ProteinSP,
  title={Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling.},
  author={David L. Brautigan},
  journal={The FEBS journal},
  year={2013},
  volume={280 2},
  pages={324-45}
}
This review traces the historical origins and conceptual developments leading to the current state of knowledge of the three superfamilies of protein Ser/Thr phosphatases. 'PR enzyme' was identified as an enzyme that inactivates glycogen phosphorylase, although it took 10 years before this ugly duckling was recognized for its true identity as a protein Ser/Thr phosphatase. Ethanol denaturation for purification in the 1970s yielded a phosphatase that exhibited broad specificity, which was… CONTINUE READING
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