Protein Separation via Polyelectrolyte Coacervation : Selectivity and Efficiency

  title={Protein Separation via Polyelectrolyte Coacervation : Selectivity and Efficiency},
  author={Ying-fan Wang and Jeff Y. Gao and Paul L Dubin},
Selective phase separation with polyelectrolytes can be used to separate a mixture of proteins. The efficiency of separation was examined using the cationic polyelectrolyte poly(diallyldimethylammonium chloride) and the model proteins bovine serum albumin, â-lactoglobulin, γ-globulin, and ribonuclease A. The coacervation yield for individual proteins and the degree of separation, for selected protein pairs, were studied as a function of polymer molecular weight, ionic strength, and pH. 


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