Protein S deficiency occurs in the nephrotic syndrome.

  title={Protein S deficiency occurs in the nephrotic syndrome.},
  author={S Vigan{\'o}-D'Angelo and Anna D'Angelo and Carol E. Kaufman and C M Sholer and Charles T. Esmon and Philip C. Comp},
  journal={Annals of internal medicine},
  volume={107 1},
Protein S activity may be compromised in patients with the nephrotic syndrome and contribute to a thrombotic diathesis. Protein S is found in two forms in plasma as free and functionally active protein S, and complexed to C4b-binding protein. When compared with controls, patients with nephrotic syndrome had reduced functional levels of protein S (69% +/- 27… CONTINUE READING