Protein S-Mycothiolation Functions as Redox-Switch and Thiol Protection Mechanism in Corynebacterium glutamicum Under Hypochlorite Stress

@inproceedings{Khanh2014ProteinSF,
  title={Protein S-Mycothiolation Functions as Redox-Switch and Thiol Protection Mechanism in Corynebacterium glutamicum Under Hypochlorite Stress},
  author={ChiBui Khanh and BuscheTobias and Van LaerKoen and B{\"a}sellKatrin and BecherD{\"o}rte and ClermontLina and M SeiboldGerd and PersickeMarcus and KalinowskiJ{\"o}rn and MessensJoris and AntelmannHaike},
  year={2014}
}
Abstract Aims: Protein S-bacillithiolation was recently discovered as important thiol protection and redox-switch mechanism in response to hypochlorite stress in Firmicutes bacteria. Here we used transcriptomics to analyze the NaOCl stress response in the mycothiol (MSH)-producing Corynebacterium glutamicum. We further applied thiol-redox proteomics and mass spectrometry (MS) to identify protein S-mycothiolation. Results: Transcriptomics revealed the strong upregulation of the disulfide stress… CONTINUE READING

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