Protein PEGylation attenuates adsorption and aggregation on a negatively charged and moderately hydrophobic polymer surface.

@article{Pai2010ProteinPA,
  title={Protein PEGylation attenuates adsorption and aggregation on a negatively charged and moderately hydrophobic polymer surface.},
  author={Sheetal S. Pai and Todd M. Przybycien and Robert D Tilton},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2010},
  volume={26 23},
  pages={18231-8}
}
Covalent grafting of poly(ethylene glycol) chains to proteins ("PEGylation") is emerging as an effective technique to increase the in vivo circulation time and efficacy of protein drugs. PEGylated protein adsorption at a variety of solid/aqueous interfaces is a critical aspect of their manufacture, storage, and delivery. A special category of block copolymer, PEGylated proteins have one or more water-soluble linear polymer (PEG) blocks and a single globular protein block that each exert… CONTINUE READING

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