Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion.

  title={Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion.},
  author={Mark Lommel and Patrick R. Winterhalter and Tobias Willer and Maik Dahlhoff and Marlon R Schneider and Markus F. Bartels and Ingrid Renner-Mueller and Thomas Ruppert and Eckhard Wolf and Sabine Strahl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 52},
In recent years protein O-mannosylation has become a focus of attention as a pathomechanism underlying severe congenital muscular dystrophies associated with neuronal migration defects. A key feature of these disorders is the lack of O-mannosyl glycans on α-dystroglycan, resulting in abnormal basement membrane formation. Additional functions of O-mannosylation are still largely unknown. Here, we identify the essential cell-cell adhesion glycoprotein epithelial (E)-cadherin as an O-mannosylated… CONTINUE READING