Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions.

@article{Yao2011ProteinO1,
  title={Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions.},
  author={David C. Yao and Yuan-shuai Huang and Xiaoran Huang and Weihuan Wang and Quanjian Yan and Lebing L Wei and Wei Xin and Stanton L. Gerson and Pamela Stanley and John B. Lowe and Lan Zhou},
  journal={Blood},
  year={2011},
  volume={117 21},
  pages={5652-62}
}
Notch signaling is essential for lymphocyte development and is also implicated in myelopoiesis. Notch receptors are modified by O-fucosylation catalyzed by protein O-fucosyltransferase 1 (Pofut1). Fringe enzymes add N-acetylglucosamine to O-fucose and modify Notch signaling by altering the sensitivity of Notch receptors to Notch ligands. To address physiologic functions in hematopoiesis of Notch modified by O-fucose glycans, we examined mice with inducible inactivation of Pofut1 using Mx-Cre… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Human deficiencies of fucosylation and sialylation affecting selectin ligands

Seminars in Immunopathology • 2012
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Roles of glycosylation in Notch signaling.

Current topics in developmental biology • 2010

Similar Papers

Loading similar papers…