Protein O-GlcNAcylation and Cardiovascular (Patho)physiology*

  title={Protein O-GlcNAcylation and Cardiovascular (Patho)physiology*},
  author={Susan A. Marsh and Helen E Collins and John C. Chatham},
  journal={The Journal of Biological Chemistry},
  pages={34449 - 34456}
Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this… 

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