Protein Networks as Logic Functions in Development and Cancer

@inproceedings{Dutkowski2011ProteinNA,
  title={Protein Networks as Logic Functions in Development and Cancer},
  author={Janusz Dutkowski and Trey Ideker},
  booktitle={PLoS Computational Biology},
  year={2011}
}
Many biological and clinical outcomes are based not on single proteins, but on modules of proteins embedded in protein networks. A fundamental question is how the proteins within each module contribute to the overall module activity. Here, we study the modules underlying three representative biological programs related to tissue development, breast cancer metastasis, or progression of brain cancer, respectively. For each case we apply a new method, called Network-Guided Forests, to identify… CONTINUE READING

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