Protein Neighbors and Proximity Proteomics*

  title={Protein Neighbors and Proximity Proteomics*},
  author={Johanna S Rees and Xue-Wen Li and Sarah Perrett and Kathryn S. Lilley and Antony P Jackson},
  booktitle={Molecular & cellular proteomics : MCP},
Within cells, proteins can co-assemble into functionally integrated and spatially restricted multicomponent complexes. Often, the affinities between individual proteins are relatively weak, and proteins within such clusters may interact only indirectly with many of their other protein neighbors. This makes proteomic characterization difficult using methods such as immunoprecipitation or cross-linking. Recently, several groups have described the use of enzyme-catalyzed proximity labeling… CONTINUE READING
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  • K. Fredriksson, C. M. Van Itallie, A. Aponte, M. Gucek, A. J. Tietgens, J. M. Anderson
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