Protein N-glycosylation determines functionality of the Saccharomyces cerevisiae cell wall integrity sensor Mid2p.

@article{Hutzler2008ProteinND,
  title={Protein N-glycosylation determines functionality of the Saccharomyces cerevisiae cell wall integrity sensor Mid2p.},
  author={Franziska Hutzler and Ronald Gerstl and Mark Lommel and Sabine Strahl},
  journal={Molecular microbiology},
  year={2008},
  volume={68 6},
  pages={1438-49}
}
The fungal cell wall is a highly dynamic structure that is essential to maintain cell shape and stability. Hence in yeasts and fungi cell wall integrity is tightly controlled. The Saccharomyces cerevisiae plasma membrane protein Mid2p is a putative mechanosensor that responds to cell wall stresses and morphological changes during pheromone induction. The extracellular domain of Mid2p, which is crucial to sensing, is highly O- and N-glycosylated. We showed that O-mannosylation is determining… CONTINUE READING
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