Protein N-glycosylation: molecular genetics and functional significance.

  title={Protein N-glycosylation: molecular genetics and functional significance.},
  author={Maria A. Kukuruzinska and Kelley Lennon},
  journal={Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists},
  volume={9 4},
Protein N-glycosylation is a metabolic process that has been highly conserved in evolution. In all eukaryotes, N-glycosylation is obligatory for viability. It functions by modifying appropriate asparagine residues of proteins with oligosaccharide structures, thus influencing their properties and bioactivities. N-glycoprotein biosynthesis involves a multitude of enzymes, glycosyltransferases, and glycosidases, encoded by distinct genes. The majority of these enzymes are transmembrane proteins… CONTINUE READING

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