Protein N-glycosylation: molecular genetics and functional significance.

@article{Kukuruzinska1998ProteinNM,
  title={Protein N-glycosylation: molecular genetics and functional significance.},
  author={Maria A. Kukuruzinska and Kelley Lennon},
  journal={Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists},
  year={1998},
  volume={9 4},
  pages={415-48}
}
Protein N-glycosylation is a metabolic process that has been highly conserved in evolution. In all eukaryotes, N-glycosylation is obligatory for viability. It functions by modifying appropriate asparagine residues of proteins with oligosaccharide structures, thus influencing their properties and bioactivities. N-glycoprotein biosynthesis involves a multitude of enzymes, glycosyltransferases, and glycosidases, encoded by distinct genes. The majority of these enzymes are transmembrane proteins… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 239 references

Cloning and expression of human Gal beta-I ,3(4)-GlcNAc alpha-2,3-sialyltransferase

  • JC
  • Biochem Biophys Res Commun 194:375-382. Klebl F…
  • 1993
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…