Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy.

@article{Merlino2017ProteinMB,
  title={Protein Metalation by Anticancer Metallodrugs: A Joint ESI MS and XRD Investigative Strategy.},
  author={Antonello Merlino and Tiziano Marzo and Luigi Messori},
  journal={Chemistry},
  year={2017},
  volume={23 29},
  pages={6942-6947}
}
Interactions of metal-based drugs with proteins and consequent adduct formation (the so-called "protein metalation" process) play a key role in the mode of action of several anticancer agents and in determining their toxicological profile. Through a novel investigative strategy grounded on the combined use of electrospray ionization mass spectrometry (ESI MS) and biological macromolecule X-ray crystallography we show that it is possible to clarify in depth the metalation process of small model… CONTINUE READING