Protein Knotting by Active Threading of Nascent Polypeptide Chain Exiting from the Ribosome Exit Channel.

  title={Protein Knotting by Active Threading of Nascent Polypeptide Chain Exiting from the Ribosome Exit Channel.},
  author={Pawel Dabrowski-Tumanski and Maciej Piejko and Szymon Niewieczerzal and Andrzej Stasiak and Joanna Ida Sulkowska},
  journal={The journal of physical chemistry. B},
  volume={122 49},
The mechanism of folding of deeply knotted proteins into their native structure is still not understood. Current thinking about protein folding is dominated by the Anfinsen dogma, stating that the structure of the folded proteins is uniquely dictated by the amino acid sequence of a given protein and that the folding is driven uniquely by the energy gained from interactions between amino acids that contact each other in the native structure of the protein. The role of ribosomes in protein… 

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