Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase.

@article{Mudhasani2016ProteinKR,
  title={Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase.},
  author={Rajini Mudhasani and Julie P. Tran and Cary J. Retterer and Krishna P. Kota and Chris A. Whitehouse and Sina Bavari},
  journal={PLoS pathogens},
  year={2016},
  volume={12 2},
  pages={e1005437}
}
Activated protein kinase R (PKR) plays a vital role in antiviral defense primarily by inhibiting protein synthesis and augmenting interferon responses. Many viral proteins have adopted unique strategies to counteract the deleterious effects of PKR. The NSs (Non-structural s) protein which is encoded by Rift Valley fever virus (RVFV) promotes early PKR… CONTINUE READING