Protein Kinase D-Mediated Anterograde Membrane Trafficking Is Required for Fibroblast Motility

Abstract

BACKGROUND Locomoting cells exhibit a constant retrograde flow of plasma membrane (PM) proteins from the leading edge lamellipodium backward, which when coupled to substrate adhesion, may drive forward cell movement. However, the intracellular source of these PM components and whether their continuous retrograde flow is required for cell motility is unknown… (More)
DOI: 10.1016/j.cub.2004.01.003

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