Protein Kinase D

  title={Protein Kinase D},
  author={Sharon A. Matthews and Enrique 4 Rozengurt and Doreen A Cantrell},
  journal={The Journal of Experimental Medicine},
  pages={2075 - 2082}
Protein kinase Cs (PKCs) are activated by antigen receptors in lymphocytes, but little is known about proximal targets for PKCs in antigen receptor-mediated responses. In this report, we define a role for diacylglycerol-regulated PKC isoforms in controlling the activity of the serine/threonine kinase protein kinase D (PKD; also known as PKC mu) in T cells, B cells, and mast cells. Antigen receptor activation of PKD is a rapid and sustained response that can be seen in T cells activated via the… CONTINUE READING


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