Protein Kinase Cr 31 and Protein Kinase C 2 Activate p 57 Mitogen-activated Protein Kinase and Block Differentiation in Colon Carcinoma Cells

@inproceedings{Sauma2005ProteinKC,
  title={Protein Kinase Cr 31 and Protein Kinase C 2 Activate p 57 Mitogen-activated Protein Kinase and Block Differentiation in Colon Carcinoma Cells},
  author={Samir Sauma and Zhongfa Van and Shigeo Ohno and Eileen Friedman},
  year={2005}
}
When HD3 colon carcinoma cells differentiate to fluidtransporting, enterocytic-like cells, they down-regulate their protein kinase C (PKC) 1 levels 5-10-fold and lose two responses to basic fibroblast growth factor (FGF): proliferation and the ability to activate p57 mitogenactivated protein (MAP) kinase. HD3 cells were transfected with expression plasmids… CONTINUE READING