Protein Kinase CK2 Is Coassembled with Small Conductance Ca2+-Activated K+ Channels and Regulates Channel Gating

@article{Bildl2004ProteinKC,
  title={Protein Kinase CK2 Is Coassembled with Small Conductance Ca2+-Activated K+ Channels and Regulates Channel Gating},
  author={Wolfgang Bildl and Tim Strassmaier and Henrike Thurm and Jens Andersen and Silke Eble and Dominik Oliver and Marlies Knipper and Matthias Mann and U. Schulte and John P Adelman and Bernd Fakler},
  journal={Neuron},
  year={2004},
  volume={43},
  pages={847-858}
}
Small conductance Ca(2+)-activated K+ channels (SK channels) couple the membrane potential to fluctuations in intracellular Ca2+ concentration in many types of cells. SK channels are gated by Ca2+ ions via calmodulin that is constitutively bound to the intracellular C terminus of the channels and serves as the Ca2+ sensor. Here we show that, in addition, the cytoplasmic N and C termini of the channel protein form a polyprotein complex with the catalytic and regulatory subunits of protein kinase… CONTINUE READING

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