Protein Kinase C Signaling Mediates a Program of Cell Cycle Withdrawal in the Intestinal Epithelium

@article{Frey2000ProteinKC,
  title={Protein Kinase C Signaling Mediates a Program of Cell Cycle Withdrawal in the Intestinal Epithelium},
  author={Mark R Frey and Jennifer A. Clark and Olga V. Leontieva and Joshua M. Uronis and Adrian R. Black and Jennifer D. Black},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={151},
  pages={763 - 778}
}
Members of the protein kinase C (PKC) family of signal transduction molecules have been widely implicated in regulation of cell growth and differentiation, although the underlying molecular mechanisms involved remain poorly defined. Using combined in vitro and in vivo intestinal epithelial model systems, we demonstrate that PKC signaling can trigger a coordinated program of molecular events leading to cell cycle withdrawal into G(0). PKC activation in the IEC-18 intestinal crypt cell line… CONTINUE READING

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Protein kinase C-mediated regulation of the cell cycle

  • J. D. Black
  • Front. Biosci. 5:D406–D423.
  • 2000
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