Protein Kinase C -Mediated Chemotaxis of Neutrophils Requires NF- B Activity but Is Independent of TNF Signaling in Mouse Skin In Vivo

Abstract

Protein kinase C (PKC) isoforms are major regulators of cutaneous homeostasis and mediate inflammation in response to 12-Otetradecanoylphorbol-13-acetate (TPA). We have previously reported that transgenic mice overexpressing PKC in the skin exhibit severe intraepidermal neutrophilic inflammation and keratinocyte apoptosis when treated topically with TPA… (More)

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