Protein Kinase C Delta Negatively Modulates Canonical Wnt Pathway and Cell Proliferation in Colon Tumor Cell Lines

@inproceedings{HernndezMaqueda2013ProteinKC,
  title={Protein Kinase C Delta Negatively Modulates Canonical Wnt Pathway and Cell Proliferation in Colon Tumor Cell Lines},
  author={Jos{\'e} G. Hern{\'a}ndez-Maqueda and Luis Bernardo Luna-Ulloa and Paula Santoyo-Ramos and Mar{\'i}a Cristina Casta{\~n}eda-Patl{\'a}n and Martha Robles-Flores},
  booktitle={PloS one},
  year={2013}
}
The tumor suppressor Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers. Alterations in Protein kinase C (PKC) isozyme expression and aberrant regulation also comprise early events in intestinal carcinomas. Here we show that PKCδ expression levels are decreased in colon tumor cell lines with respect to non-malignant cells. Reciprocal co-immunoprecipitation and immunofluorescence studies revealed that PKCδ interacts specifically with both full-length (from non… CONTINUE READING
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Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function

  • Y Xing, WK Clements, I Le Trong, TR Hinds, R Stenkamp
  • Mol Cell
  • 2004
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